Article 13120

Title of the article

THE INVOLVEMENT PROPROTEIN CONVERTASE SUBTILISIN/KEXIN OF TYPE 9 IN THE PATHOGENESIS OF ATHEROSCLEROSIS (LITERATURE REVIEW) 

Authors

Chaulin Aleksey Mikhaylovich, Assistant, sub-department of histology and embryology, Samara State Medical University (89, Chapayevskaya street, Samara, Russia); doctor, Samara Regional Cardiology Dispensary (43, Aerodromnaya street, Samara, Russia), E-mail: alekseymichailovich22976@gmail.com 

Index UDK

616.1 

DOI

10.21685/2072-3032-2020-1-13 

Abstract

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is now considered an important contributor to the pathogenesis of atherosclerosis. The article describes the history of the discovery of PCSK9, the structure, functions and stages of biosynthesis of this molecule. PCSK9, through promoting lysosomal degradation of hepatic low-density lipoprotein receptor (LDLR), can decrease the clearance of plasma LDL, leading to hypercholesterolemia and formation atherosclerotic plaque formation. PCSK9 is a new therapeutic target for the treatment of hypercholesterolemia. New lipid-lowering drugs – PCSK9 inhibitors – are more effective than statins. Some studies have shown the involvement of PCSK9 in the inflammatory mechanisms of atherosclerosis. 

Key words

proprotein convertase subtilisin/kexin type 9 (PCSK9), atherosclerosis, cholesterol, low-density lipoproteins (LDL), low-density lipoprotein receptors (LDLR), inflammation 

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Дата создания: 20.05.2020 12:50
Дата обновления: 20.05.2020 15:36